The 135-kilometer (84-mile) railway, which will link mining operations to a river terminal, will cost an estimated $1.2 billion and is expected to start operations in 2022.
Most workers at Gold Fields' struggling South Deep mine have been on strike since Nov. 2 over the company's plans to cut around 1,100 jobs, or 30% of its workforce.
La Mancha is a private gold company with investments in Toronto-listed Endeavour Mining, Australia's Evolution Mining and Ghana-focused Golden Star Resources.
The mine is 307 km northwest of the nation’s capital of Accra, and is situated along the Sefwi Volcanic Belt, a northeast-southwest trending volcanic belt in western Ghana.
Minister of Mines and Mining Development, Winston Chitando told Reuters there would be "no change" for diamonds and platinum when asked about industry speculation the indigenisation rules could be relaxed further.
On Jan. 1, the London Bullion Market Association will introduce a new version of the guidelines that embrace what’s called environmental, social and governance standards.